The Entourage Effect

A plant to represent natural medicine

The cannabis plant contains a complex array of chemical compounds, including cannabinoids, terpenes, and flavonoids. 

While much attention has been given to individual components like THC (tetrahydrocannabinol) and CBD (cannabidiol), researchers are increasingly interested in how these compounds interact with each other. This phenomenon is known as “The Entourage Effect.”

What is the Entourage Effect?

The entourage effect is a theory proposing that the various compounds in cannabis work together synergistically, potentially influencing the overall effects of the plant. This concept suggests that the combined action of multiple components may differ from the effects of individual compounds in isolation.


Cannabinoids are a class of compounds found in cannabis. THC and CBD are the most well-known, but there are over 120 different cannabinoids identified to date. Each may have distinct properties and interact with our endocannabinoid system as well as other cannabis compounds. We explore Cannabinoids in greater detail in this blog.


Terpenes are aromatic compounds responsible for the distinct scents of different cannabis strains. Common terpenes include myrcene, limonene, and pinene. Different strains of the cannabis plant have their unique mix of terpenes, which is sometimes called their “terpene profile.” You can also find terpenes in other things like tea, thyme, Spanish sage, and citrus fruits such as lemon, orange, and mandarin.

Terpenes are researched to have various medicinal properties. For a more in-depth look into Terpenes, the different scents and their potential health benefits, read our dedicated blog


Flavonoids are another group of compounds found in cannabis and many other plants. Whilst research is limited, what we do know about Flavonoids is that they contribute to plant colour and flavour. Specifically within the cannabis plant, 20 varieties of flavonoids have been found with each impacting potential health benefits differently – from inflammation to cardiovascular, studies are currently ongoing.

The presence or absence of various compounds within any form of natural medicine may influence the potential for entourage effects.

Interestingly, the concept of synergistic interactions between plant compounds is not unique to cannabis. Similar ideas have been explored in other botanical contexts, such as traditional herbal medicine practices. At Astrid, we actively spotlight research that informs the health impacts of plants holistically. If you have any questions, please contact our team on (03) 9077 2446 or hello@astrid.health, or visit one of our dispensaries